User profiles for "author:Normand G"

Guillaume Normand

Novartis
Verified email at novartis.com
Cited by 1947

Understanding cytokinesis failure

G Normand, RW King�- Polyploidization and cancer, 2010 - Springer
Cytokinesis is the final step in cell division. The process begins during chromosome
segregation, when the ingressing cleavage furrow begins to partition the cytoplasm between�…

Review of an initial experience with an experimental spectral photon-counting computed tomography system

S Si-Mohamed, D Bar-Ness, M Sigovan…�- Nuclear Instruments and�…, 2017 - Elsevier
Spectral photon-counting CT (SPCCT) is an emerging X-ray imaging technology that
extends the scope of available diagnostic imaging tools. The main advantage of photon�…

[HTML][HTML] A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion

M Overholtzer, AA Mailleux, G Mouneimne, G Normand…�- Cell, 2007 - cell.com
Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell
death program termed anoikis. Here we describe a nonapoptotic cell death program in�…

MACUSTAR: development and clinical validation of functional, structural, and patient-reported endpoints in intermediate age-related macular degeneration

RP Finger, S Schmitz-Valckenberg, M Schmid…�- …, 2019 - karger.com
Purpose: Currently, no outcome measures are clinically validated and accepted as clinical
endpoints by regulatory agencies for drug development in intermediate age-related macular�…

A non-genetic route to aneuploidy in human cancers

M Krajcovic, NB Johnson, Q Sun, G Normand…�- Nature cell�…, 2011 - nature.com
Aneuploidy is common in human tumours and is often indicative of aggressive disease.
Aneuploidy can result from cytokinesis failure, which produces binucleate cells that generate�…

Structure of : Intruder -Wave Strength at

SD Pain, WN Catford, NA Orr, JC Ang�lique…�- Physical review�…, 2006 - APS
The breaking of the N= 8 shell-model magic number in the Be 12 ground state has been
determined to include significant occupancy of the intruder d-wave orbital. This is in marked�…

Gadolinium-encapsulating iron oxide nanoprobe as activatable NMR/MRI contrast agent

S Santra, SD Jativa, C Kaittanis, G Normand, J Grimm…�- ACS�…, 2012 - ACS Publications
Herein we report a novel gadolinium-encapsulating iron oxide nanoparticle-based
activatable NMR/MRI nanoprobe. In our design, Gd-DTPA is encapsulated within the poly�…

Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions

JP Holland, G Normand, A Ruggiero…�- Molecular�…, 2011 - journals.sagepub.com
Imaging the location and extent of cancer provides invaluable information before, during,
and after surgery. The majority of “image-guided” methods that use, for example, positron�…

Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells

A Hasenj�ger, B Gillissen, A M�ller, G Normand…�- Oncogene, 2004 - nature.com
The mitochondrial apoptosis pathway mediates cell death through the release of various pro-
apoptotic factors including cytochrome c and Smac, the second mitochondrial activator of�…

HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti‐apoptotic functions through the PKA signaling pathway

MT Simon, A Pauloin, G Normand, HT Lieu…�- The FASEB�…, 2003 - Wiley Online Library
ABSTRACT The HIP/PAP (= human Reg‐2) C‐type lectin encoding gene is activated in
primary liver cancers. In normal liver, the protein is undetectable in normal mature�…