Abstract Introduction Hepatitis C virus (HCV) is a major public health threat. Although the
recent availability of highly effective directly acting antivirals created optimism towards HCV�…

C-type lectin receptors (CLRs) are important pattern recognition receptors involved in
recognition and induction of adaptive immunity to pathogens. Certain CLRs play an�…

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and
developing germ cells,. Deletion of Nanog causes early embryonic lethality, whereas�…

Poly-ADP-ribosylation is a post-translational modification catalyzed by PARP enzymes with
roles in transcription and chromatin biology. Here we show that distinct macrodomains�…

Quantitative fluorescence and superresolution microscopy are often limited by insufficient
data quality or artifacts. In this context, it is essential to have biologically relevant control�…

We present a real-time fitter for 3D single-molecule localization microscopy using
experimental point spread functions (PSFs) that achieves minimal uncertainty in 3D on any�…

Facilitates chromatin transcription (FACT) is a conserved histone chaperone that
reorganizes nucleosomes and ensures chromatin integrity during DNA transcription�…

At the beginning of mammalian life, the genetic material from each parent meets when the
fertilized egg divides. It was previously thought that a single microtubule spindle is�…

Gene tagging with fluorescent proteins is essential for investigations of the dynamic
properties of cellular proteins. CRISPR–Cas9 technology is a powerful tool for inserting�…

ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD+ onto
substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as�…