OBJECTIVE: To examine the association between the outcomes of a pre-operative
comprehensive geriatric assessment (CGA) and the risk of severe post-operative�…

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled�…

Background It has been evident for a while that the result after resection for colon cancer
may not have been optimal. Several years ago, this was showed by some leading surgeons�…

Background Few studies have evaluated the long-term functional outcome after anastomotic
leakage in the treatment of rectal cancer. Methods Between 1993 and 1998, 147 patients�…

Background: Urinary and sexual dysfunction are recognized complications of rectal excision
for cancer. The aim of this study was to examine the frequency of such complications after�…

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal�…

Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to�…

Objective Anastomotic leakage is a potentially serious complication of low anterior resection
which may be accompanied by clinical symptoms (clinical leak) or may be silent (subclinical�…

Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises�…

Background Microsatellite instability (MSI) was suggested as a marker for good prognosis in
colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010�…