Trisomic and monosomic (aneuploid) embryos account for at least 10% of human
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence�…

INTRODUCTION Mammals generate sexually dimorphic germ cells, oocytes and
spermatozoa, which form the basis for sexual reproduction. Studies in mice have shown that�…

Segregation of homologs at the first meiotic division (MI) is facilitated by crossovers and by a
physical constraint imposed on sister kinetochores that facilitates monopolar attachment to�…

The reaction rates (kr) of 5, 7-diisopropyl-tocopheroxyl radical (Toc) with catechins
(epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), epigallocatechin�…

In vivo reprogramming provokes a wide range of cell fate conversion. Here, we discover that
in vivo induction of higher levels of OSKM in mouse somatic cells leads to increased�…

The mammalian germline is characterized by extensive epigenetic reprogramming during its
development into functional eggs and sperm. Specifically, the epigenome requires resetting�…

Increasing age in a woman is a well-documented risk factor for meiotic errors, but the effect
of paternal age is less clear. Although it is generally agreed that spermatogenesis declines�…

Meiosis is a fundamental process that underpins sexual reproduction. In mammals, the
execution of meiosis is tightly integrated within the complex processes of oogenesis and�…

Kinetic study of the aroxyl radical-scavenging action of catechins (epicatechin (EC),
epicatechin gallate (ECG), epigallocatechin (EGC), and epigallocatechin gallate (EGCG))�…

The origin of most ovarian tumors is undefined. Here, we report development of a novel
mouse model in which conditional inactivation of the tumor suppressor gene Rb1 in oocytes�…