After encountering antigen, helper T (TH) cells undergo differentiation to effector cells, which
can secrete high levels of interferon-γ, interleukin-4 (IL-4), IL-10 and other�…

The recognition of polarized T cell subsets defined by cytokine production was followed by a
search to define the factors controlling this phenomenon. Suitable in vitro systems allowed�…

The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity
but substantial plasticity for development down distinct effector or regulatory lineages�…

Abstract Interleukin 12 (IL-12) is an inducible cytokine composed of 35-and 40-kDa subunits
that is critical for promoting T helper type 1 development and cell-mediated immunity against�…

CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although
the precise mechanisms that control their development are undefined. Here we present data�…

In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs,
a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice�…

Although in vitro observations suggest that cross-presentation of antigens is mediated
primarily by CD8α+ dendritic cells, in vivo analysis has been hampered by the lack of�…

It is estimated that familial aggregation and genetic susceptibility play a role in as many as
10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in�…

Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid
tissues, the transcription factors controlling their development and their relationship to other�…

We develop a theory of rational addiction in which rationality means a consistent plan to
maximize utility over time. Strong addiction to a good requires a big effect of past�…