There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using�…

Wnt/�-catenin signalling is a widespread cell signalling pathway with multiple roles during
vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ߠ…

The transcription factor Oct4 is required in vitro for establishment and maintenance of
embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it�…

The activity of Wnt and Notch signalling is central to many cell fate decisions during
development and to the maintenance and differentiation of stem cell populations in�…

The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is required
for somatic hypermutation and class switch recombination at the immunoglobulin locus. In�…

The pluripotent state is traditionally associated with large absolute levels of certain
transcription factors such as Nanog and Oct4. Here, we present experimental observations�…

Pluripotency in embryonic stem cells is maintained through the activity of a small set of
transcription factors centred around Oct4 and Nanog, which control the expression of 'self�…

During dorsal closure, the lateral epithelia on each side of the embryo migrate dorsally over
the amnioserosa and fuse at the dorsal midline. Detailed genetic studies have revealed that�…

Diabetes in pregnancy is associated with an increased risk of poor outcomes, both for the
mother and her offspring. Although clinical and epidemiological studies are invaluable to�…

Background Due to the large amount of data produced by advanced microscopy, automated
image analysis is crucial in modern biology. Most applications require reliable cell nuclei�…