[HTML][HTML] Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells
T Kalmar, C Lim, P Hayward, S Mu�oz-Descalzo…�- PLoS�…, 2009 - journals.plos.org
There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using�…
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using�…
Wnt/ss-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells
S Mu�oz-Descalzo, AK Hadjantonakis…�- Seminars in cell &�…, 2015 - Elsevier
Wnt/�-catenin signalling is a widespread cell signalling pathway with multiple roles during
vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ߠ…
vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ߠ…
Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst
GC Le Bin, S Mu�oz-Descalzo, A Kurowski…�- …, 2014 - journals.biologists.com
The transcription factor Oct4 is required in vitro for establishment and maintenance of
embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it�…
embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it�…
Wnt‐Notch signalling: An integrated mechanism regulating transitions between cell states
The activity of Wnt and Notch signalling is central to many cell fate decisions during
development and to the maintenance and differentiation of stem cell populations in�…
development and to the maintenance and differentiation of stem cell populations in�…
Correlations between the levels of Oct4 and Nanog as a signature for na�ve pluripotency in mouse embryonic stem cells
S Mu�oz Descalzo, P Ru�, J Garcia-Ojalvo…�- Stem�…, 2012 - academic.oup.com
The pluripotent state is traditionally associated with large absolute levels of certain
transcription factors such as Nanog and Oct4. Here, we present experimental observations�…
transcription factors such as Nanog and Oct4. Here, we present experimental observations�…
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
R Kumar, L DiMenna, N Schrode, TC Liu, P Franck…�- Nature, 2013 - nature.com
The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is required
for somatic hypermutation and class switch recombination at the immunoglobulin locus. In�…
for somatic hypermutation and class switch recombination at the immunoglobulin locus. In�…
A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells
S Mu�oz Descalzo, P Ru�, F Faunes…�- Molecular systems�…, 2013 - embopress.org
Pluripotency in embryonic stem cells is maintained through the activity of a small set of
transcription factors centred around Oct4 and Nanog, which control the expression of 'self�…
transcription factors centred around Oct4 and Nanog, which control the expression of 'self�…
In vivo and in vitro models of diabetes: a focus on pregnancy
J Lilao-Garz�n, C Valverde-Tercedor…�- Diabetes: from Research�…, 2021 - Springer
Diabetes in pregnancy is associated with an increased risk of poor outcomes, both for the
mother and her offspring. Although clinical and epidemiological studies are invaluable to�…
mother and her offspring. Although clinical and epidemiological studies are invaluable to�…
[HTML][HTML] Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling
During dorsal closure, the lateral epithelia on each side of the embryo migrate dorsally over
the amnioserosa and fuse at the dorsal midline. Detailed genetic studies have revealed that�…
the amnioserosa and fuse at the dorsal midline. Detailed genetic studies have revealed that�…
[HTML][HTML] Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition
B Mathew, A Schmitz, S Mu�oz-Descalzo, N Ansari…�- BMC�…, 2015 - Springer
Background Due to the large amount of data produced by advanced microscopy, automated
image analysis is crucial in modern biology. Most applications require reliable cell nuclei�…
image analysis is crucial in modern biology. Most applications require reliable cell nuclei�…