As high‐throughput techniques including proteomics become more accessible to individual
laboratories, there is an urgent need for a user‐friendly bioinformatics analysis system�…

Human colorectal cancer cell lines are used widely to investigate tumor biology,
experimental therapy, and biomarkers. However, to what extent these established cell lines�…

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the
normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations�…

Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate�…

OBJECTIVES: Microsatellite instability (MSI) is an established marker of good prognosis in
colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated�…

Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are
prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating�…

Abstract Purpose: PIK3CA and PTEN mutations are prevalent in colorectal cancer and
potential markers of response to mitogen-activated protein/extracellular signal–regulated�…

We describe a statistical method for the characterization of genomic aberrations in single
nucleotide polymorphism microarray data acquired from cancer genomes. Our approach�…

Background Molecular indicators of colorectal cancer prognosis have been assessed in
several studies, but most analyses have been restricted to a handful of markers. We aimed�…