The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is
induced at high levels in migratory and other responding cells by proinflammatory stimuli�…

Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required�…

Abstract Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory�…

HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into
multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the�…

TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular
body (MVB), where they interact with other Endosomal Sorting Complex Required for�…

To investigate roles in intestinal inflammation for the 2 cyclooxygenase (COX) isoforms, we
determined susceptibility to spontaneous and induced acute colitis in mice lacking either the�…

Two isoforms of cyclooxygenase (COX) are known, and to date most studies have implicated
COX-2, rather than COX-1, as the isoform involved in colon carcinogenesis. In the present�…

Mice carrying a null mutation for either of the two cyclooxygenase (COX) isoenzymes,
necessary for prostanoid production, exhibit several isotype-specific reproductive�…

Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis in
humans and in rodents. These drugs are believed to act by inhibiting one or both of the�…

Topoisomerase I has ubiquitous roles in important cellular functions such as replication,
transcription, and recombination. In order to further characterize this enzyme in vivo, we�…