Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions�…

Cytogenetic investigations of neoplastic cells during the past 25 years have revealed more
than 600 acquired, recurrent, balanced chromosome rearrangements, and it has been�…

Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural
balanced rearrangements are associated with distinct tumor subtypes with remarkable�…

This publication combines and extends the now classic system of human cytogenetic
nomenclature that has been prepared by expert committees and published in, or in�…

Cytogenetic studies over the past few decades have revealed clonal chromosomal
aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated�…

The first three editions of this acclaimed book presented a much-needed conceptual
synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a�…

Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in�…

Abstract The recurrent translocation t (8; 16)(p11; p13) is a cytogenetic hallmark for the
M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated�…

To assess the distribution of gains and losses of genetic material in malignant solid
neoplasms, 11 tumor types for which at least 100 short-term cultured cases with clonal�…

It has long been known that rearrangements of chromosomes through breakage-fusion-
bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell�…