Obesity is associated with chronic low-grade inflammation in peripheral tissues caused, in
part, by the recruitment of inflammatory monocytes into adipose tissue. Studies in rodent�…

Objective To determine interrelationships between the expression of long intergenic
(noncoding) RNA–p21 (lincRNA‐p21), NF‐κB activity, and responses to methotrexate (MTX)�…

Lung organogenesis requires precise timing and coordination to effect spatial organization
and function of the parenchymal cells. To provide a systematic broad-based view of the�…

Background & Aims The enteric nervous system (ENS) coordinates essential intestinal
functions through the concerted action of diverse enteric neurons (ENs). However�…

Common genetic variants confer substantial risk for chronic lung diseases, including
pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific�…

Mass and fluorescence cytometry are quantitative single cell flow cytometry approaches that
are powerful tools for characterizing diverse tissues and cellular systems. Here mass�…

WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in
the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in�…

Common genetic variants confer substantial risk for chronic lung diseases, including
pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type�…

Cellular metabolism influences immune cell function, with mitochondrial fatty acid β-
oxidation and oxidative phosphorylation required for multiple immune cell phenotypes�…

WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context
in a range of chromatin-centric processes. WDR5 is also a prominent target for�…