Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with�…

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence�…

Checkpoints suppress improper cell cycle progression to ensure that cells maintain the
integrity of their genome. During mitosis, a metaphase checkpoint requires the integration of�…

Measurements of tubulin exchange into and from bovine brain microtubules at steady state
in vitro were made with 3H-GTP as a marker for tubulin addition to or loss from microtubules�…

The genetic aetiologies of at least 20% of autosomal dominant spinocerebellar ataxias
(SCAs) have yet to be elucidated 1. We have recently identified a novel form of autosomal�…

Pleckstrin homology (PH) domains may act as membrane localization modules through
specific interactions with phosphoinositide phospholipids. These interactions could�…

Huntington's disease (HD) is an autosomal dominant disorder characterized by
abnormalities of movement, cognition, and emotion and selective atrophy of the striatum and�…

The neurodegenerative diseases Huntington disease, dentatorubropallidoluysian atrophy,
spinocerebellar atrophy type 3, and spinal bulbar muscular atrophy are caused by�…

Parkinson disease (PD) is a neurodegenerative disease characterized by tremor,
bradykinesia, rigidity and postural instability. Post-mortem examination shows loss of�…

A “spindle assembly” checkpoint has been described that arrests cells in G1 following
inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here�…