Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom�…

The kinetochore is a control module that both powers and regulates chromosome
segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably�…

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated�…

It is now clear that a centrosome-independent pathway for mitotic spindle assembly exists
even in cells that normally possess centrosomes. The question remains, however, whether�…

Proper organization of microtubule arrays is essential for intracellular trafficking and cell
motility. It is generally assumed that most if not all microtubules in vertebrate somatic cells�…

We have performed a biochemical and double-stranded RNA-mediated interference (RNAi)
analysis of the role of two chromosomal passenger proteins, inner centromere protein�…

Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator,
a process known as chromosome congression. Centromere-associated protein E (CENP�…

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more�…

One of the most intriguing aspects of mitosis is the ability of kinetochores to hold onto plus
ends of microtubules that are actively gaining or losing tubulin subunits. Here, we show that�…

The motion of a chromosome during mitosis is mediated by a bundle of microtubules, termed
a kinetochore fibre (K-fibre), which connects the kinetochore of the chromosome to a spindle�…