Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen,
the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53�…

Cells from some tumors use an altered metabolic pattern compared with that of normal
differentiated adult cells in the body. Tumor cells take up much more glucose and mainly�…

Arnold J. Levine negatively regulated by the adenovirus E1B-55Kd protein and the human
MDM2 protein. In both cases, p53 Department of Molecular Biology amino acid residues 22�…

DNA clones of the wild-type p53 proto-oncogene inhibit the ability of ElA plus ras or mutant
p53 plus rasactivated oncogenes to transform primary rat embryo fibroblasts. The rare�…

Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human
anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has�…

SV40 infection or transformation of murine cells stimulated the production of a 54K dalton
protein that was specifically immunoprecipitated, along with SV40 large T and small t�…

Oligonucleotide arrays can provide a broad picture of the state of the cell, by monitoring the
expression level of thousands of genes at the same time. It is of interest to develop�…

Activation of the p53 tumor suppressor protein has been demonstrated to block cell growth
by inducing either a transient cell cycle arrest or programmed cell death (apoptosis)�…

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion�…

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