Affinity maturation of receptor–ligand interactions represents an important area of academic
and pharmaceutical research. Improving affinity and specificity of proteins can tailor potency�…

Histopathology is insufficient to predict disease progression and clinical outcome in lung
adenocarcinoma. Here we show that gene-expression profiles based on microarray analysis�…

The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of
leukocytes, including T cells and natural killer (NK) cells,,. Considerable effort has been�…

Published studies agree that transient intraocular pressure (IOP) spikes are common after
intravitreal injections of anti–vascular endothelial growth factor agents. Currently, there is no�…

Purpose We compared the outcome of breast-conserving surgery and radiotherapy in
BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls�…

Gut microbiota bacterial depletions and altered metabolic activity at 3 months are implicated
in childhood atopy and asthma. We hypothesized that compositionally distinct human�…

Wnts are lipid-modified morphogens that play critical roles in development principally
through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8�…

BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1
gene provides potentially valuable information to women at high risk of breast or ovarian�…

CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated
destruction. Here, we modified the binding domain of human SIRPα, the receptor for CD47�…

Background Sustained cardiac adrenergic stimulation has been implicated in the
development and progression of heart failure. Release of norepinephrine is controlled by�…