Interaction of regulatory DNA binding proteins with their target sites is usually preceded by
binding to nonspecific DNA. This speeds up the search for the target site by several orders of�…

Here we review recent studies on the mode of action of the cholinergic anthelmintics
(levamisole, pyrantel etc.). We also include material from studies on the free living nematode�…

Introns are removed from pre-mRNAs during transcription while the pre-mRNA is still
tethered to the gene locus via RNA polymerase. However, during alternative splicing, it is�…

l-[−]-2, 3, 5, 6-Tetrahydro-6-phenylimidazo [2, 1b]-thiazole hydrochloride (levamisole) is an
anthelmintic that targets the nicotinic acetylcholine receptors of parasitic nematodes. We�…

What are the thermodynamic consequences of the stepwise conversion of a highly specific
(consensus) protein-DNA interface to one that is non-specific? How do the magnitudes of�…

We are interested in the positive allosteric modulation of neuronal nicotinic acetylcholine
(ACh) receptors and have recently shown that the anthelmintic compound morantel�…

We have investigated the molecular determinants responsible for α-bungarotoxin (αBgtx)
binding to nicotinic acetylcholine receptors through chimeric analysis of two homologous α�…

The interaction oflacoperator DNA withlacrepressor (LacI) is a classic example of a genetic
regulatory switch. To dissect the role of stoichiometry, subunit association, and effects of�…

We are interested in the properties of the target site of cholinergic anti-nematodal drugs for
therapeutic reasons. The target receptors are ligand-gated ion channels that have different�…

This paper will provide a comprehensive overview on the liquid optically clear adhesive
(LOCA) technologies display assembly, including materials, application process, and�…