User profiles for "author:Leung CT"

Chi Tat LEUNG

Canon Electronic Business Machines (Hong Kong) Co. Ltd.
Verified email at cebm.canon.com.hk
Cited by 944

[HTML][HTML] The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease

SYY Pang, PWL Ho, HF Liu, CT Leung, L Li…�- Translational�…, 2019 - Springer
Background Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the
substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During�…

Contribution of olfactory neural stem cells to tissue maintenance and regeneration

CT Leung, PA Coulombe, RR Reed�- Nature neuroscience, 2007 - nature.com
The olfactory neuroepithelium undergoes continual neurogenesis and, after extensive
lesions, fully regenerates to maintain sensory function. The stem cell population underlying�…

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments

CT Leung, JS Brugge�- Nature, 2012 - nature.com
Tumorigenesis is a clonal evolution process that is initiated from single cells within
otherwise histologically normal tissue. It is unclear how single, sporadic mutant cells that�…

Regulation of epididymal principal cell functions by basal cells: role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1)

GPH Leung, KH Cheung, CT Leung, MW Tsang…�- Molecular and cellular�…, 2004 - Elsevier
The epithelia lining the epididymides of many species including the human are known to
consist of several cell types. Among them, the principal cells are the most abundant and their�…

[HTML][HTML] Deubiquitinases in cancers: aspects of proliferation, metastasis, and apoptosis

J Liu, CT Leung, L Liang, Y Wang, J Chen, KP Lai…�- Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current DUBs findings that correlate with the
most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung�…

Oncogene-like induction of cellular invasion from centrosome amplification

SA Godinho, R Picone, M Burute, R Dagher, Y Su…�- Nature, 2014 - nature.com
Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly�…

Neural network based short-term load forecasting using weather compensation

TWS Chow, CT Leung�- IEEE transactions on power systems, 1996 - ieeexplore.ieee.org
This paper presents a novel technique for electric load forecasting based on neural weather
compensation. Our proposed method is a nonlinear generalization of Box and Jenkins�…

A neural-based crowd estimation by hybrid global learning algorithm

SY Cho, TWS Chow, CT Leung�- IEEE Transactions on�…, 1999 - ieeexplore.ieee.org
A neural-based crowd estimation system for surveillance in complex scenes at underground
station platform is presented. Estimation is carried out by extracting a set of significant�…

In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis

EJ Kim, CT Leung, RR Reed…�- Journal of�…, 2007 - Soc Neuroscience
In the adult mammalian brain, new neurons and glia are continuously generated but
molecular factors regulating their differentiation and lineage relationships are largely�…

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for�…

PWL Ho, CT Leung, H Liu, SYY Pang, CSC Lam…�- Autophagy, 2020 - Taylor & Francis
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with
misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA�…