Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the�…

Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent
work has strengthened the proposal that mutational alterations conferring instability occur�…

In contrast to normal cells, aneuploidy—alterations in the number of chromosomes—is
consistently observed in virtually all cancers. A growing body of evidence suggests that�…

After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell
cycle. It is shown here that this arrest could be sustained only when p53 was present in the�…

The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-
subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many�…

To gain a molecular understanding of tumor angiogenesis, we compared gene expression
patterns of endothelial cells derived from blood vessels of normal and malignant colorectal�…

It has long been considered that genetic instability is an integral component of human
neoplasia1–3. In a small fraction of tumours, mismatch repair deficiency leads to a�…

It has been shown that bone marrow–derived stem cells can form a major fraction of the
tumor endothelium in mouse tumors. To determine the role of such cells in human tumor�…

Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in
G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase�…

We have examined the effects of commonly used chemotherapeutic agents on human colon
cancer cell lines in which the p53 pathway has been specifically disrupted by targeted�…