The epileptic encephalopathies are conditions in which neurological deterioration is
attributable entirely or partly to epileptic activity and is due to very frequent or severe�…

Epilepsy is often associated with cognitive and behavioral impairments that can have
profound impact on the quality of life of patients. Although the mechanisms of cognitive�…

Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in
SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal�…

Place cells are hippocampal neurons whose discharge is strongly related to a rat's location
in its environment. The existence of place cells has led to the proposal that they are part of�…

Finding one's way in space requires a distributed neural network to support accurate spatial
navigation. In the rat, this network likely includes the hippocampus and its place cells�…

Objective: We investigated whether interictal epileptiform discharges (IED) in the human
hippocampus are related to impairment of specific memory processes, and which�…

Objective Cognitive impairment is common in epilepsy, particularly in memory function.
Interictal spikes (IISs) are thought to disrupt cognition, but it is difficult to delineate their�…

In the hippocampus, pyramidal cells encode information in two major ways: rate coding and
temporal coding. Rate coding, in which information is coded through firing frequency, is�…

This study examined the performance of spatial problems by rats when purely behavioral
manipulations disturb the relationship between the place cell representation and the cues�…

Hippocampus place cell discharge is an important model system for understanding
cognition, but evidence is missing that the place code is under the kind of dynamic�…