Background Pembrolizumab monotherapy showed durable antitumour activity and
manageable safety in patients with metastatic triple-negative breast cancer. We aimed to�…

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming�…

After the cellular prion protein (PrPC) transits to the cell surface where it is bound by a
glycophosphatidyl inositol (GPI) anchor, PrPC is either metabolized or converted into the�…

Neuronal death and vacuolation are characteristics of the CNS degeneration found in prion
diseases. Relatively few cultured cell lines have been identified that can be persistently�…

Spectral variants of green fluorescent protein are widely used in live samples for a broad
range of applications: from visualization of protein interactions, through following gene�…

The causation, structural origin, and mechanism of formation of spongiform lesions in
transmissible encephalopathies are unknown. We have used immunogold electron�…

Background Alzheimer's disease (AD) is the most common type of dementia, affecting one in
eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown�…

Dementia with Lewy bodies (DLB), Parkinson's disease (PD) and multiple system atrophy
are characterized by the deposition of disease-associated α-synuclein. In the present study�…

The prion encephalopathies are characterized by accumulation in the brain of the abnormal
form PrPsc of a normal host gene product PrPc. The mechanism and site of formation of�…

The novel basic, heat-stable tubulin polymerization promoting protein TPPP/p25 is
associated with microtubules in vitro and can induce the formation of aberrant microtubule�…