A “spindle assembly” checkpoint has been described that arrests cells in G1 following
inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here�…

Metaphase checkpoint controls sense abnormalities of chromosome alignment during
mitosis and prevent progression to anaphase until proper alignment has been attained. A�…

Survivin, a dimeric baculovirus inhibitor of apoptosis repeat (BIR) motif protein that is
principally expressed in G2 and mitosis, has been associated with protection against�…

Protein phosphatase-1 (PP-1) is involved in the regulation of numerous metabolic processes
in mammalian cells. The major isoforms of PP-1, α, γ1, and δ, have nearly identical catalytic�…

A high degree of aneuploidy characterizes the majority of human tumors. Aneuploid status
can arise through mitotic or cleavage failure coupled with failure of tetraploid G1 checkpoint�…

Abstract p21WAF1 and 14-3-3σ, which are both transcriptional products of p53, have been
reported to play a role in the G2 DNA damage checkpoint in mammalian cells. Human colon�…

Mammalian cells in culture normally enter a state of quiescence during G1 following
suppression of cell cycle progression by senescence, contact inhibition or terminal�…

DNA damage by double-strand breaks induces arrest during interphase in mammalian cells.
It is not clear whether DNA damage can arrest cells in mitosis. We show here that three�…

Taxol (paclitaxel) induces a microtubule hyperassembled state, and effectively blocks cells
in mitosis. Here we report that Taxol also induces a stable late-G1 block in nontransformed�…

Hepatitis B X-interacting protein (HBXIP) is a ubiquitous protein that was originally identified
as a binding partner of the hepatitis B viral protein HBx. HBXIP is also thought to serve as an�…