Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most�…

Growth experiments are routinely used to analyze basic properties of a given organism or
cellular model. Similarly, within the TRANSLUCENT project the characterization of cellular�…

Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome
missegregation events in aneuploid cells promote chromosomal instability (CIN) that may�…

Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics
with a poorly understood mechanism of action. We identified a set of genes repressed in�…

Background The APOBEC3 family of cytidine deaminases mutate the cancer genome in a
range of cancer types. Although many studies have documented the downstream effects of�…

Background: Chromosomal instability (CIN) is thought to be associated with poor prognosis
in solid tumors; however, evidence from preclinical and mouse tumor models suggest that�…

Background Understanding the cancer genome is seen as a key step in improving outcomes
for cancer patients. Genomic assays are emerging as a possible avenue to personalised�…

Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN)
and numerical or whole chromosomal CIN (W-CIN). Recent work indicated that replication�…

Chromosomal instability (CIN) is associated with poor outcome in epithelial malignancies,
including breast carcinomas. Evidence suggests that prognostic signatures in estrogen�…

Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently
observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient�…