Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse
species; however, its effect on resistance to illness and mortality in primates has not been�…

Magnetic resonance imaging (MRI) studies of non-human primates are becoming
increasingly common; however, the well-developed voxel-based methodologies used in�…

Voxel-based morphometry studies have become increasingly common in human
neuroimaging over the past several years; however, few studies have utilized this method to�…

Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age
and may contribute to neural atrophy in humans. We investigated IL-6 associations with age�…

Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in
many species, including nonhuman primates, although the effect on the brain is less well�…

Rhesus macaques on a calorie restricted diet (CR) develop less age-related disease, have
virtually no indication of diabetes, are protected against sarcopenia, and potentially live�…

Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in
many species, including nonhuman primates, although the effect on the brain is less well�…

Higher serum homocysteine (Hcy) levels in humans are associated with vascular pathology
and greater risk for dementia, as well as lower global and regional volumes in frontal lobe�…

Background: 11C PIB PET has been shown to correlate with the presence of brain amyloid
in patients with neurodegenerative disease. The short half-life of 11C makes the clinical use�…

Methods Rhesus macaques were recruited from an ongoing study at the Wisconsin National
Primate Research Center. Hand dominance was assessed by expert observers based on�…