Artificial intelligence in healthcare

KH Yu, AL Beam, IS Kohane�- Nature biomedical engineering, 2018 - nature.com
Artificial intelligence (AI) is gradually changing medical practice. With recent progress in
digitized data acquisition, machine learning and computing infrastructure, AI applications�…

Using electronic health records to drive discovery in disease genomics

IS Kohane�- Nature Reviews Genetics, 2011 - nature.com
If genomic studies are to be a clinically relevant and timely reflection of the relationship
between genetics and health status—whether for common or rare variants—cost-effective�…

[HTML][HTML] What every reader should know about studies using electronic health record data but may be afraid to ask

IS Kohane, BJ Aronow, P Avillach…�- Journal of medical�…, 2021 - jmir.org
Coincident with the tsunami of COVID-19–related publications, there has been a surge of
studies using real-world data, including those obtained from the electronic health record�…

[HTML][HTML] The co-morbidity burden of children and young adults with autism spectrum disorders

IS Kohane, A McMurry, G Weber, D MacFadden…�- PloS one, 2012 - journals.plos.org
Objectives Use electronic health records Autism Spectrum Disorder (ASD) to assess the
comorbidity burden of ASD in children and young adults. Study Design A retrospective�…

Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks

AJ Butte, P Tamayo, D Slonim…�- Proceedings of the�…, 2000 - National Acad Sciences
In an effort to find gene regulatory networks and clusters of genes that affect cancer
susceptibility to anticancer agents, we joined a database with baseline expression levels of�…

Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements

AJ Butte, IS Kohane�- Biocomputing 2000, 1999 - World Scientific
Increasing numbers of methodologies are available to find functional genomic clusters in
RNA expression data. We describe a technique that computes comprehensive pair-wise�…

[HTML][HTML] Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

N Barda, N Dagan, C Cohen, MA Hern�n, M Lipsitch…�- The Lancet, 2021 - thelancet.com
Background Many countries are experiencing a resurgence of COVID-19, driven
predominantly by the delta (B. 1.617. 2) variant of SARS-CoV-2. In response, these countries�…

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski…�- Nature�…, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide�…

[PDF][PDF] Microarrays for an integrative genomics

IS Kohane, AT Kho, AJ Butte - 2003 - ir.juit.ac.in
Three years ago, when a colleague would approach us with questions about functional
genomics and the informatics techniques required to leverage the data obtained from�…

Reestablishing the researcher-patient compact

IS Kohane, KD Mandl, PL Taylor, IA Holm, DJ Nigrin…�- Science, 2007 - science.org
However, researchers do not know who the patient is and so broadcast to the system of the
IC—conditional on the ICOB editorial process and approval—a description of the kind of�…