Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through
the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by�…

In the last 5 years, many features of the control of the cell cycle have been clarified. The
mitotic cycle is now understood as a biochemical pathway that generates from within the cell�…

We review the recent advances in understanding transitions within the cell cycle. These
have come from both genetic and biochemical approaches. We discuss the phylogenetic�…

A heat stable protein essentail for microtubule assembly has been isolated. This protein,
which we designate tau (tau), is present in association with tubulin purified from porcine�…

Peptide growth factors may play a role in patterning of the early embryo, particularly in the
induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early�…

Two biologists tackle the unresolved question in the field of evolution: how have living
organisms on Earth developed with such variety and complexity? In the 150 years since�…

Cyclin degradation is the key step governing exit from mitosis and progress into the next cell
cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a�…

A vertebrate securin (vSecurin) was identified on the basis of its biochemical analogy to the
Pds1p protein of budding yeast and the Cut2p protein of fission yeast. The vSecurin protein�…

We describe a novel 25 kDa protein, geminin, which inhibits DNA replication and is
degraded during the mitotic phase of the cell cycle. Geminin has a destruction box sequence�…

Rac signalling to actin—a pathway that is thought to be mediated by the protein Scar/WAVE
(WASP (Wiskott–Aldrich syndrome protein)-family verprolin homologous protein)—has a�…