▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other
proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic�…

▪ Abstract Clathrin-based systems are responsible for a large portion of vesicular traffic
originating from the plasma membrane and the trans-Golgi network that reaches the�…

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical�…

Dynamin is essential for clathrin-dependent coated vesicle formation. It is required for
membrane budding at a late stage during the transition from a fully formed pit to a pinched�…

Clathrin-coated vesicles carry traffic from the plasma membrane to endosomes. We report
here the real-time visualization of cargo sorting and endocytosis by clathrin-coated pits in�…

INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing�…

Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the
underlying membrane. How does this process start? We used live-cell TIRF imaging with�…

The large GTPase dynamin is essential for clathrin‐dependent coated‐vesicle formation.
Dynasore is a cell‐permeable small molecule that inhibits the GTPase activity of dynamin1�…

Although small GTP-binding proteins of the Rho family have been implicated in signaling to
the actin cytoskeleton, the exact nature of the linkage has remained obscure. We describe a�…

Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins
mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast�…