Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through
the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by�…

In the last 5 years, many features of the control of the cell cycle have been clarified. The
mitotic cycle is now understood as a biochemical pathway that generates from within the cell�…

A review of: flower initiation/differentiation (herbaceous angiosperms, woody angiosperms,
and conifers); flower development and gibberellins (floral organogenesis and pollination;�…

Small molecules that perturb specific protein functions are valuable tools for dissecting
complex processes in mammalian cells. A combination of two phenotype-based screens�…

Field observations and satellite geodesy indicate that little crustal shortening has occurred
along the central to southern margin of the eastern Tibetan plateau since about 4 million�…

Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system.
We have fractionated mitotic Xenopus egg extracts to identify components required for this�…

Abstract On 12 May 2008, a magnitude 7.9 earthquake ruptured the Longmen Shan margin
of the eastern Tibetan plateau. This event occurred within the context of long-term uplift and�…

GAMIT/GLOBK is a comprehensive GPS analysis package developed at MIT, the Harvard-
Smithsonian Center for Astrophysics (CfA), and the Scripps Institution of Oceanography�…

Proteasomes, the primary mediators of ubiquitin–protein conjugate degradation, are
regulated through complex and poorly understood mechanisms. Here we show that USP14�…

We present and interpret Global Positioning System (GPS) measurements of crustal motions
for the period 1988–1994 at 54 sites extending east‐west from the Caucasus mountains of�…