A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or
disturbances that would otherwise drive them away from a desirable steady state. The�…

Light has become established as a tool not only to visualize and investigate but also to steer
biological systems. This review starts by discussing the unique features that make light such�…

This article introduces the finite state projection (FSP) method for use in the stochastic
analysis of chemically reacting systems. One can describe the chemical populations of such�…

Homeostasis is a recurring theme in biology that ensures that regulated variables robustly—
and in some systems, completely—adapt to environmental perturbations. This robust perfect�…

The ability to adapt to stimuli is a defining feature of many biological systems and critical to
maintaining homeostasis. While it is well appreciated that negative feedback can be used to�…

In his splendid article “Can a biologist fix a radio?—or, what I learned while studying
apoptosis,” Y. Lazebnik argues that when one uses the right tools, similarity between a�…

A central challenge in computational modeling of biological systems is the determination of
the model parameters. Typically, only a fraction of the parameters (such as kinetic rate�…

Although much has been done to elucidate the biochemistry of signal transduction and gene
regulatory pathways, it remains difficult to understand or predict quantitative responses. We�…

Molecular biology studies the cause-and-effect relationships among microscopic processes
initiated by individual molecules within a cell and observes their macroscopic phenotypic�…

Dynamic control of gene expression can have far-reaching implications for biotechnological
applications and biological discovery. Thanks to the advantages of light, optogenetics has�…