Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the�…

In a flipped classroom, students study instructional material before class and apply this
material during class. To provide a statistical synthesis of current research on effects of�…

It is often assumed that interventions aimed at supporting students' self-regulated learning
(SRL) are effective for improving achievement because these interventions support SRL�…

In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor�…

Complex learning aims at the integration of knowledge, skills, and attitudes; the coordination
of qualitatively different constituent skills; and the transfer of what is learned to daily life or�…

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are�…

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of�…

Single-cell transcriptomics has recently emerged as a powerful technology to explore gene
expression heterogeneity among single cells. Here we identify two major sources of�…

Central nervous system tumours represent one of the most lethal cancer types, particularly
among children. Primary treatment includes neurosurgical resection of the tumour, in which�…

Single-cell genomics and single-cell transcriptomics have emerged as powerful tools to
study the biology of single cells at a genome-wide scale. However, a major challenge is to�…