MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors
M Kato, J Zhang, M Wang, L Lanting…�- Proceedings of the�…, 2007 - National Acad Sciences
Key features of diabetic nephropathy (DN) include the accumulation of extracellular matrix
proteins such as collagen 1-α 1 and-2 (Col1a1 and-2). Transforming growth factor β1 (TGF�…
proteins such as collagen 1-α 1 and-2 (Col1a1 and-2). Transforming growth factor β1 (TGF�…
Guidelines for the Management of Helicobacter pylori Infection in Japan: 2009 Revised Edition
M Asaka, M Kato, S Takahashi, Y Fukuda…�- …, 2010 - Wiley Online Library
Background: Over the past few years, the profile of Helicobacter pylori infection has changed
in Japan. In particular, the relationship between H. pylori and gastric cancer has been�…
in Japan. In particular, the relationship between H. pylori and gastric cancer has been�…
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
M Kato, MS Patel, R Levasseur, I Lobov…�- The Journal of cell�…, 2002 - rupress.org
The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor.
Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass�…
Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass�…
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
M Kato, S Putta, M Wang, H Yuan, L Lanting, I Nair…�- Nature cell�…, 2009 - nature.com
Akt kinase is activated by transforming growth factor-β1 (TGF-β) in diabetic kidneys, and has
important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells�…
important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells�…
Electrostatic basis for enzyme catalysis
Enzymatic reactions play a fundamentally important role in controlling and performing most
life processes. 1-3 Thus, understanding how enzymes work has both fundamental and�…
life processes. 1-3 Thus, understanding how enzymes work has both fundamental and�…
New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions�…
S Kato, M Takikawa, K Nakashima…�- …�Lateral Sclerosis and�…, 2000 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that
primarily involves the motor neuron system. Approximately 5-10% of ALS is familial�…
primarily involves the motor neuron system. Approximately 5-10% of ALS is familial�…
Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label�…
K Fukase, M Kato, S Kikuchi, K Inoue, N Uemura…�- The Lancet, 2008 - thelancet.com
Summary Background The relation between Helicobacter pylori infection and gastric cancer
has been proven in epidemiological studies and animal experiments. Our aim was to�…
has been proven in epidemiological studies and animal experiments. Our aim was to�…
Frequent inactivation of A20 in B-cell lymphomas
M Kato, M Sanada, I Kato, Y Sato, J Takita, K Takeuchi…�- Nature, 2009 - nature.com
A20 is a negative regulator of the NF-κB pathway and was initially identified as being rapidly
induced after tumour-necrosis factor-α stimulation. It has a pivotal role in regulation of the�…
induced after tumour-necrosis factor-α stimulation. It has a pivotal role in regulation of the�…
Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea
M Kato, P Roberts-Thomson, BG Phillips, WG Haynes…�- Circulation, 2000 - Am Heart Assoc
Background—Patients with obstructive sleep apnea (OSA) experience repetitive episodic
hypoxemia with consequent sympathetic activation and marked blood pressure surges�…
hypoxemia with consequent sympathetic activation and marked blood pressure surges�…
[HTML][HTML] Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels
Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many
proteins within these bodies contain KH or RRM RNA-binding domains as well as low�…
proteins within these bodies contain KH or RRM RNA-binding domains as well as low�…