The cell biology of the early processes of mammalian embryogenesis, such as germ-layer
formation, has been technically challenging to study owing to the size and accessibility of�…

Preparation of specific lineages at high purities from embryonic stem (ES) cells requires both
selective culture conditions and markers to guide and monitor the differentiation. In this�…

The neural fate is generally considered to be the intrinsic direction of embryonic stem (ES)
cell differentiation. However, little is known about the intracellular mechanism that leads�…

Expression of the Wnt modulator secreted frizzled related protein 4 (Sfrp4) is upregulated
after heart ischemic injury. We show that intramuscular administration of recombinant Sfrp4�…

Endothelial cells (ECs) are thought to be derived mainly from the vascular endothelial
growth factor receptor 2 (VEGFR-2)+ lateral mesoderm during early embryogenesis. In this�…

OBJECTIVE: Cord blood banks provide fully human leukocyte antigen− typed cells, from
which a set of standard induced pluripotent stem (iPS) cells for use in allogenic�…

Micronutrient status of parents can affect long term health of their progeny. Around 2 billion
humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a�…

Background Drugs inhibiting vascular endothelial growth factor (VEGF) signaling are
globally administered to suppress deregulated angiogenesis in a variety of eye diseases�…

Genome studies in fish provide evidence for the adaptability of the vertebrate immune
system, revealing alternative immune strategies. The reported absence of the major�…

From a list of protein kinases (PKs) that are newly induced upon differentiation of mouse
embryonic stem cells to mesendoderm, we identified a previously uncharacterized kinase�…