Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
R Jaenisch, A Bird�- Nature genetics, 2003 - nature.com
Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these�…
functionally heterogeneous owing to the differential expression of genes. Many of these�…
[HTML][HTML] Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
R Jaenisch, R Young�- Cell, 2008 - cell.com
Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been
achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most�…
achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most�…
Nuclear reprogramming and pluripotency
K Hochedlinger, R Jaenisch�- Nature, 2006 - nature.com
The cloning of mammals from differentiated donor cells has refuted the old dogma that
development is an irreversible process. It has demonstrated that the oocyte can�…
development is an irreversible process. It has demonstrated that the oocyte can�…
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
M Wernig, A Meissner, R Foreman, T Brambrink, M Ku…�- Nature, 2007 - nature.com
Nuclear transplantation can reprogramme a somatic genome back into an embryonic
epigenetic state, and the reprogrammed nucleus can create a cloned animal or produce�…
epigenetic state, and the reprogrammed nucleus can create a cloned animal or produce�…
Polycomb complexes repress developmental regulators in murine embryonic stem cells
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the
ability to differentiate into virtually all adult cell types are not well understood. Polycomb�…
ability to differentiate into virtually all adult cell types are not well understood. Polycomb�…
MyoD or Myf-5 is required for the formation of skeletal muscle
MA Rudnicki, PNJ Schnegelsberg, RH Stead, T Braun…�- Cell, 1993 - cell.com
Mice carrying null mutations in the myogenic regulatory factors Myf-5 or YyoD have
apparently normal skeletal muscle. To address whether these two factors functionally�…
apparently normal skeletal muscle. To address whether these two factors functionally�…
[HTML][HTML] Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may�…
characteristics, raising the question of whether an earlier," naive" state of pluripotency may�…
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
D Hockemeyer, F Soldner, C Beard, Q Gao…�- Nature�…, 2009 - nature.com
Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent
stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques�…
stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques�…
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
The Myf-5 gene, a member of the myogenic basic HLH factor family, has been inactivated in
mice after homologous recombination in ES cells. Mice lacking Myf-5 were unable to�…
mice after homologous recombination in ES cells. Mice lacking Myf-5 were unable to�…
[HTML][HTML] One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
The type II bacterial CRISPR/Cas system is a novel genome-engineering technology with
the ease of multiplexed gene targeting. Here, we created reporter and conditional mutant�…
the ease of multiplexed gene targeting. Here, we created reporter and conditional mutant�…