The circulation of the deep Atlantic Ocean during the height of the last ice age appears to
have been quite different from today. We review observations implying that Atlantic�…

This review analyzes the issues associated with biodegradation of glyphosate (N-
(phosphonomethyl) glycine), one of the most widespread herbicides. Glyphosate can�…

The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of
debate, in large part because of the lack of insight into underlying mechanisms. Here we�…

A long-standing hypothesis on tumorigenesis is that cell division failure, generating
genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies�…

Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed
MGUS. The factors underlying the malignant transformation of MGUS are unknown. We�…

Previous studies have established that a subset of head and neck tumors contains human
papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display�…

The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors is limited
by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is�…

A hallmark feature of glioblastoma is its strong self-renewal potential and immature
differentiation state, which contributes to its plasticity and therapeutic resistance. Here�…

Purpose: The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by
gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer�…

BACKGROUND. Immune checkpoint blockade improves survival in a subset of patients with
non–small-cell lung cancer (NSCLC), but robust biomarkers that predict response to PD-1�…