Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones�…

High-throughput gene expression screens provide a quantitative picture of the average
expression signature of biological samples. However, the analysis of spatial gene�…

The mammalian liver consists of hexagon-shaped lobules that are radially polarized by
blood flow and morphogens,,,. Key liver genes have been shown to be differentially�…

Complex biological, technological, and sociological networks can be of very different sizes
and connectivities, making it difficult to compare their structures. Here we present an�…

A detailed depiction of the'integrin adhesome', consisting of a complex network of 156
components linked together and modified by 690 interactions is presented. Different views of�…

Complex networks are studied across many fields of science. To uncover their structural
design principles, we defined “network motifs,” patterns of interconnections occurring in�…

Highlights•Cells in tissues operate in structured microenvironments.•Studying division of
labor in tissues requires spatially-resolved transcriptomics.•This is enabled by highly�…

Empiric probiotics are commonly consumed by healthy individuals as means of life quality
improvement and disease prevention. However, evidence of probiotic gut mucosal�…

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD�…

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver�…