Summary The Drosophila Groucho (Gro) protein was the founding member of the family of
transcriptional co-repressor proteins that now includes the transducin-like enhancer of split�…

THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as
receptor, are key components in a lateral-inhibition signalling pathway that regulates the�…

We have identified and characterized c-hairy1, an avian homolog of the Drosophila
segmentation gene, hairy. c-hairy1 is strongly expressed in the presomitic mesoderm, where�…

We present a procedure for cosmid cloning that allows rapid and efficient cloning of
individual DNA fragments of between 32kb and 45kb. By appropriate treatment of the�…

Background: Neurons of the vertebrate central nervous system (CNS) are generated
sequentially over a prolonged period from dividing neuroepithelial progenitor cells. Some�…

Localization of cytoplasmic messenger RNA transcripts is widely used to target proteins
within cells. For many transcripts, localization depends on cis-acting elements within the�…

We have used the interaction trap, a yeast two-hybrid system, to identify proteins Interacting
with hairy, a basic-helix-loop-helix (bHLH) protein that represses transcription during�…

Abstract X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the
early embryonic nervous system in scattered cells that appear to be the prospective primary�…

Delta-Notch signalling regulates cell-fate choices in a variety of tissues during development.
We report the expression of Delta4 (Dl4) in arterial endothelium during mouse�…

Relatively little is known about the molecular mechanisms involved in transcriptional
repression, despite its importance in development and differentiation. Recent evidence�…