The p53 protein is essential for the implementation of the cellular response to challenging
environmental conditions. Reacting to stochastic nutrient stress, p53 integrates the activity of�…

Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally,
ROS levels are tightly controlled by an inducible antioxidant program that responds to�…

Activating KRAS mutations are found in nearly all cases of pancreatic ductal
adenocarcinoma (PDAC), yet effective clinical targeting of oncogenic KRAS remains elusive�…

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of
enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could�…

In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven�…

Numerous mechanisms to support cells under conditions of transient nutrient starvation
have been described. Several functions of the tumor-suppressor protein p53 can contribute�…

The p53 transcription factor coordinates wide-ranging responses to stress that contribute to
its function as a tumour suppressor. The responses to p53 induction are complex and range�…

Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage
targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD�…

Background In response to oncogenic stress, the tumour suppressor protein p53 can induce
the elimination of cells through induction of cell death or senescence, helping to restrain�…

The p53 tumor suppressor protein is a potent activator of proliferative arrest and cell death.
In normal cells, this pathway is restrained by p53 protein degradation mediated by the E3�…