Retroviral Gag protein is capable of directing the assembly of virion particles independent of
other retroviral elements and plays an important role early in the infection of a cell. Using the�…

The human brain undergoes extensive and dynamic growth during the first years of life. The
UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects�…

Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from�…

We discovered that many proteins located in the kinetochore outer domain, but not the inner
core, are depleted from kinetochores and accumulate at spindle poles when ATP production�…

During mammalian brain development, immature neurons migrate radially from the
neuroectoderm to defined locations, giving rise to characteristic cell layers,. Here we show�…

Background: To test current models for how unattached and untense kinetochores prevent
Cdc20 activation of the anaphase-promoting complex/cyclosome (APC/C) throughout the�…

The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning
during brain development. We have found that the intracellular Dab1 protein receives a�…

Disabled gene products are important for nervous system development in drosophila and
mammals. In mice, the Dab1 protein is thought to function downstream of the extracellular�…

The large extracellular matrix protein Reelin is produced by Cajal-Retzius neurons in
specific regions of the developing brain, where it controls neuronal migration and�…

The spindle checkpoint prevents errors in chromosome segregation by inhibiting anaphase
onset until all chromosomes have aligned at the spindle equator through attachment of their�…