Bipolar affective disorders linked to DNA markers Page 1 NATURE VOL. 325 26 FEBRUARY
1987 ARTICLES 783 Bipolar affective disorders linked to DNA markers on chromosome 11�…

Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal�…

The therapeutic responsiveness of genetically defined tumors expressing or devoid of the
p53 tumor suppressor gene was compared in immunocompromised mice. Tumors�…

Although the primary cellular targets of many anticancer agents have been identified, less is
known about the processes leading to the selective cell death of cancer cells or the�…

APOPTOSIS is a genetically encoded programme of cell death that can be activated under
physiological conditions1, 2 and may be an important safeguard against tumour�…

Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary
DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide�…

The Huntington's disease (HD) gene has been mapped in 4p16. 3 but has eluded
identification. We have used haplotype analysis of linkage disequilibrium to spotlight a small�…

We have isolated a series of genomic and cDNA clones mapping within the boundaries of
constitutional and tumor deletions that define the Wilms' tumor locus on human chromsome�…

cAMP (3′, 5′ cyclic adenosine monophosphate) is a second messenger that in eukaryotic
cells induces physiological responses ranging from growth, differentiation, and gene�…

Mutations at the W locus in the mouse have pleiotropic effects on embryonic development
and hematopoiesis. The characteristic phenotype of mutants at this locus, which includes�…