Abstract Analysis of the mechanisms underlying cell fates requires the molecular
quantification of cellular features. Classical techniques use population average readouts at�…

The constant regeneration of the blood system during hematopoiesis requires tightly
controlled lineage decisions of hematopoietic progenitor cells (HPCs). Because of technical�…

The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-
affiliated transcription factors, with the capacity for lineage reprogramming, positive auto�…

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem�…

Maintaining cellular redox balance is vital for cell survival and tissue homoeostasis because
imbalanced production of reactive oxygen species (ROS) may lead to oxidative stress and�…

Differentiation alters molecular properties of stem and progenitor cells, leading to changes in
their shape and movement characteristics. We present a deep neural network that�…

Figure 1 Continuous single-cell quantification with tTt and qTfy.(a) Iterative image analysis
workflow of tTt: graphical overview of raw data for inspection and loading only of relevant�…

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver�…

Background In recent years, high-throughput microscopy has emerged as a powerful tool to
analyze cellular dynamics in an unprecedentedly high resolved manner. The amount of data�…

The existence of specialized liver stem cell populations, including AXIN2+ pericentral
hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using�…