Involvement of the Notch signaling pathway in vascular development has been
demonstrated by both gain-and loss-of-function mutations in humans, mice, and zebrafish. In�…

Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of�…

Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the�…

THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as
receptor, are key components in a lateral-inhibition signalling pathway that regulates the�…

Background: Neurons of the vertebrate central nervous system (CNS) are generated
sequentially over a prolonged period from dividing neuroepithelial progenitor cells. Some�…

We have identified and characterized c-hairy1, an avian homolog of the Drosophila
segmentation gene, hairy. c-hairy1 is strongly expressed in the presomitic mesoderm, where�…

Abstract X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the
early embryonic nervous system in scattered cells that appear to be the prospective primary�…

Notch signaling is known to differentially affect the development of lymphoid B and T cell
lineages, but it remains unclear whether such effects are specifically dependent on distinct�…

ABSTRACT Mouse delta-like 3 (Dll3), a novel vertebrate homologue of the Drosophila gene
Delta was isolated by a subtracted library screen. In Drosphila, the Delta/Notch signalling�…

Somitic segmentation provides the framework on which the segmental pattern of the
vertebrae, some muscles and the peripheral nervous system is established. Recent�…