Results of various cancer genome sequencing projects have “unexpectedly” challenged the
framework of the current somatic gene mutation theory of cancer. The prevalence of diverse�…

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non�…

Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could�…

Endothelial nitric oxide (NO) synthase is a unique NO synthase isoform that is expressed
constitutively by vascular endothelium both in vivo and in vitro and is believed essential to�…

Fluorescence in situ hybridization to metaphase chromosomes or chromatin fibers in
interphase nuclei is a powerful technique in mapping genes and DNA segments to specific�…

Histone acetylation plays an important role in regulating chromatin structure and thus gene
expression. Here we describe the functional characterization of HDAC4, a human histone�…

Endoplasmic Reticulum (ER) stress refers to a condition of accumulation of unfolded or
misfolded proteins in the ER lumen. A variety of biochemical stimuli or pathophysiologic�…

We describe here the identification and functional characterization of a novel human histone
acetyltransferase, termed MORF (monocytic leukemia zinc finger protein-related factor)�…

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common�…

Cancer is traditionally labeled a “cellular growth problem.” However, it is fundamentally an
issue of macroevolution where new systems emerge from tissue by breaking various�…