The recent rate of emergence of pathogenic fungi that are resistant to the limited number of
commonly used antifungal agents is unprecedented. The azoles, for example, are used not�…

Durable crop protection is an essential component of current and future food security.
However, the effectiveness of pesticides is threatened by the evolution of resistant�…

Fungicides are widely used in developed agricultural systems to control disease and
safeguard crop yield and quality. Over time, however, resistance to many of the most�…

Background: Microsatellite instability (MSI) is seen in 10%–15% of sporadic colorectal
cancers mostly in the right colon, but the precursors of cancers with MSI remain unknown�…

Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the
body (a germ-line epimutation) have a predisposition for the development of cancer in a�…

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory
autocrine and paracrine signals, involving overexpression of secreted peptide growth�…

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the
normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations�…

Abstract Purpose: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the
tumor growth factor β (TGF-β) superfamily. Several observations suggest that it plays a role�…

Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on�…