WT1 is a tumor suppressor gene with a key role in urogenital development and the
pathogenesis of Wilms' tumor. Two alternative splice sites in the WT1 transcript allow the�…

Over the years, many apparently contradictory findings and functions have been ascribed to
the protein product of the WT1 tumour suppressor gene. These include being a�…

The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple�…

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for�…

WE have hypothesized that end-to-end chromosome fusions observed in some tumours
could play a part in genetic instability associated with tumorigenesis and that fusion may�…

SMALL eye (Sey) in mouse is a semidominant mutation which in the homozygous condition
results in the complete lack of eyes and nasal primordia. On the basis of comparative�…

Based on the map location of the aniridia (AN) locus in human chromosomal band 11p13,
we have cloned a candidate AN cDNA (D11S812E) that is completely or partially deleted in�…

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three�…

Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500�…

Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we�…