Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

E Abranches, AMV Guedes, M Moravec…�- …, 2014 - journals.biologists.com
Heterogeneous expression of the transcription factor NANOG has been linked to the
existence of various functional states in pluripotent stem cells. This heterogeneity seems to�…

[HTML][HTML] Valence tautomerism in a cobalt–dioxolene complex containing an imidazolic ancillary ligand

AMV Guedes, LS de Abreu, IAV Maldonado…�- RSC�…, 2023 - pubs.rsc.org
This work reports the synthesis, structural, spectroscopic and magnetic investigation of two
complexes,[Co (bmimapy)(3, 5-DTBCat)] PF6� H2O (1) and [Co (bmimapy)(TCCat)] PF6�…

[HTML][HTML] Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic�…

Y Sanchez-Ripoll, HK Bone, T Owen, AMV Guedes…�- PloS one, 2013 - journals.plos.org
Maintenance of embryonic stem cell (ESC) self-renewal and pluripotency are controlled by
extrinsic factors, molecular signaling pathways and transcriptional regulators. While many of�…

[HTML][HTML] Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation

G Nair, E Abranches, AMV Guedes, D Henrique…�- Scientific reports, 2015 - nature.com
Populations of cultured mouse embryonic stem cells (ESCs) exhibit a subfraction of cells
expressing uncharacteristically low levels of pluripotency markers such as Nanog. Yet, the�…

The influence of thioether-substituted ligands in dicopper (II) complexes: Enhancing oxidation and biological activities

DC Durigon, VA Glitz, BF Pimenta, AMV Guedes…�- Journal of Inorganic�…, 2024 - Elsevier
This paper describes the synthesis, structural analysis, as well as the magnetic and
spectroscopic characterizations of three new dicopper (II) complexes with dinucleating�…

Dissecting transcriptional heterogeneity in pluripotency: single cell analysis of mouse embryonic stem cells

AMV Guedes, D Henrique, E Abranches�- Stem Cell Heterogeneity�…, 2016 - Springer
Abstract Mouse Embryonic Stem cells (mESCs) show heterogeneous and dynamic
expression of important pluripotency regulatory factors. Single-cell analysis has revealed the�…

Imaging Pluripotency: Time-Lapse Analysis of Mouse Embryonic Stem Cells

A Pezzarossa, AMV Guedes, D Henrique…�- Embryonic Stem Cell�…, 2016 - Springer
The current view of the pluripotent state is that of a transient, dynamic state, maintained by
the balance between opposing cues. Understanding how this dynamic state is established�…