Recent advances in single-cell sequencing hold great potential for exploring biological
systems with unprecedented resolution. Sequencing the genome of individual cells can�…

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear�…

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are�…

microRNAs are small noncoding genes that regulate the protein production of genes by
binding to partially complementary sites in the mRNAs of targeted genes. Here, using our�…

MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary
sites in the 3′ untranslated regions of target genes in animals and, by unknown�…

The human liver is an essential multifunctional organ. The incidence of liver diseases is
rising and there are limited treatment options. However, the cellular composition of the liver�…

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune�…

The extent of microglial heterogeneity in humans remains a central yet poorly explored
question in light of the development of therapies targeting this cell type. Here, we investigate�…

To understand organ function, it is important to have an inventory of its cell types and of their
corresponding marker genes. This is a particularly challenging task for human tissues like�…

Microglia have critical roles not only in neural development and homeostasis, but also in
neurodegenerative and neuroinflammatory diseases of the central nervous system,,–. These�…