Impact of risk factors on early cancer evolution
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than�…
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than�…
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new�…
the characterization of emerging subclones, which seed metastatic sites, might offer new�…
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two�…
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two�…
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
EC De Bruin, N McGranahan, R Mitter, M Salm…�- Science, 2014 - science.org
Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal�…
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal�…
[HTML][HTML] Control of Smad7 stability by competition between acetylation and ubiquitination
E Gr�nroos, U Hellman, CH Heldin, J Ericsson�- Molecular cell, 2002 - cell.com
Smad proteins regulate gene expression in response to TGFβ signaling. Here we present
evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in�…
evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in�…
[HTML][HTML] Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients�…
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients�…
[HTML][HTML] The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven�…
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven�…
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress
E Gr�nroos, AA Terentiev, T Punga…�- Proceedings of the�…, 2004 - National Acad Sciences
The tumor suppressor p53 regulates cell-cycle progression and apoptosis in response to
genotoxic stress, and inactivation of p53 is a common feature of cancer cells. The levels and�…
genotoxic stress, and inactivation of p53 is a common feature of cancer cells. The levels and�…
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories
RE Hynds, KK Frese, DR Pearce…�- Open�…, 2021 - royalsocietypublishing.org
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths
worldwide. Although advances are being made towards earlier detection and the�…
worldwide. Although advances are being made towards earlier detection and the�…
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…