In individual cells, transcription is a random process obeying single-molecule kinetics. Often,
it occurs in a bursty, intermittent manner. The frequency and size of these bursts affect the�…

Protein levels have been shown to vary substantially between individual cells in clonal
populations. In prokaryotes, the contribution to such fluctuations from the inherent�…

We track the motion of individual fluorescently labeled mRNA molecules inside live E. coli
cells. We find that the motion is subdiffusive, with an exponent that is robust to physiological�…

Gene activity is described by the time series of discrete, stochastic mRNA production events.
This transcriptional time series shows intermittent, bursty behavior. One consequence of this�…

We describe a method for tracking RNA molecules in Escherichia coli that is sensitive to
single copies of mRNA, and, using the method, we find that individual molecules can be�…

When the process of cell-fate determination is examined at single-cell resolution, it is often
observed that individual cells undergo different fates even when subject to identical�…

Transcription is a highly stochastic process. To infer transcription kinetics for a gene-of-
interest, researchers commonly compare the distribution of mRNA copy-number to the�…

Determining the growth patterns of single cells offers answers to some of the most elusive
questions in contemporary cell biology: how cell growth is regulated and how cell size�…

MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common
drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to�…

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To
identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA�…