Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects�…

Centrioles are microtubule-derived structures that are essential for the formation of
centrosomes, cilia and flagella. The centrosome is the major microtubule organiser in animal�…

Precise control of centrosome number is crucial for bipolar spindle assembly and accurate
transmission of genetic material to daughter cells. Failure to properly control centrosome�…

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra�…

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because�…

Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell–
dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this�…

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly�…

Tandemly repeated ribosomal DNA (rDNA) arrays are among the most evolutionary dynamic
loci of eukaryotic genomes. The loci code for essential cellular components, yet exhibit�…

T cell activation is associated with a profound and rapid metabolic response to meet
increased energy demands for cell division, differentiation and development of effector�…

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in
their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the�…