Differences in lung anatomy between mice and humans, as well as frequently disappointing
results when using animal models for drug discovery, emphasise the unmet need for in vitro�…

Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried�…

Transcription factors (TFs) and their networks are central effectors controlling pluripotency
(Young, 2011). Numerous involved TFs have been identified, but a subset of core�…

Objective—To determine the role of Gja5 that encodes for the gap junction protein
connexin40 in the generation of arteriovenous malformations in the hereditary hemorrhagic�…

Lung epithelial progenitors differentiate into alveolar type 1 (AT1) and type 2 (AT2) cells.
These cells form the air-blood interface and secrete surfactant, respectively, and are�…

One of the recent breakthroughs in stem cell research has been the reprogramming of
human somatic cells to an embryonic stem cell (ESC)-like state (induced pluripotent stem�…

Transposon gene delivery systems offer an alternative, non-viral-based approach to
generate induced pluripotent stem cells (iPSCs). Here we used the Sleeping Beauty (SB)�…

Background & Aim Glioblastoma is an aggressive brain cancer with no effective treatments
and a prognosis of 12-15 months. Immune system effector T cells are a promising therapy�…

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic vascular
disease that affects 1 in 5000 individuals worldwide 1. The abnormal vascular structures in�…

PSCs, both ESCs and iPSCs are already a useful and renewable source of all cell types of
the body. PSCs enable the generation of autologous cells for the in vitro investigation of�…