Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer
During disease progression the cells that comprise solid malignancies undergo significant
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…
Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones
NS Cheung, CJ Pascoe, SF Giardina, CA John…�- …, 1998 - Elsevier
Excitotoxicity induced by l-glutamate (Glu), when examined in a pure neuronal cortical
culture, involved widespread apoptosis at concentrations of 1–10 μM as part of a continuum�…
culture, involved widespread apoptosis at concentrations of 1–10 μM as part of a continuum�…
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer
YW Cheng, H Pincas, MD Bacolod, G Schemmann…�- Clinical Cancer�…, 2008 - AACR
Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown�…
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown�…
Reversible assembly of proteolysis targeting chimeras
PROteolysis TArgeting Chimeras (PROTACs) are of significant current interest for the
development of probe molecules and drug leads. However, they suffer from certain�…
development of probe molecules and drug leads. However, they suffer from certain�…
Novel, self-assembling dimeric inhibitors of human β tryptase
SF Giardina, DS Werner, M Pingle…�- Journal of medicinal�…, 2020 - ACS Publications
β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central
pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge�…
pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge�…
Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis
SF Giardina, M Mikami, F Goubaeva, J Yang�- Biochemical and biophysical�…, 2007 - Elsevier
The current study aimed to understand the anti-apoptotic effect of overexpressed gap
junction forming protein connexin (Cx) 43 in C6 glioma cells. C6 cells exposed to hydrogen�…
junction forming protein connexin (Cx) 43 in C6 glioma cells. C6 cells exposed to hydrogen�…
Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies
MD Bacolod, GS Schemmann, SF Giardina, P Paty…�- Cancer research, 2009 - AACR
High-density single nucleotide polymorphism (SNP) mapping arrays have identified
chromosomal features whose importance to cancer predisposition and progression is not yet�…
chromosomal features whose importance to cancer predisposition and progression is not yet�…
GROα is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1
Y Wen, SF Giardina, D Hamming, J Greenman…�- Clinical cancer�…, 2006 - AACR
Purpose: The growth-related oncogene α (GROα) is a secreted interleukin-like molecule that
interacts with the CXCR2 G-protein–coupled receptor. We found that the mRNA and protein�…
interacts with the CXCR2 G-protein–coupled receptor. We found that the mRNA and protein�…
Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): a modular platform for generating reversible, self-assembling bifunctional targeted degraders
Proteolysis-Targeting Chimeras (PROTACs) are bifunctional molecules that bring a target
protein and an E3 ubiquitin ligase into proximity to append ubiquitin, thus directing target�…
protein and an E3 ubiquitin ligase into proximity to append ubiquitin, thus directing target�…
PROTACs: Promising approaches for epigenetic strategies to overcome drug resistance
Epigenetic modulation of gene expression is essential for tissue-specific development and
maintenance in mammalian cells. Disruption of epigenetic processes, and the subsequent�…
maintenance in mammalian cells. Disruption of epigenetic processes, and the subsequent�…